Rasberry Case Insights Mesotrione
Effect  first discovered decades ago as that little grew under the bottle brush tree Callistemon citrinus.

Mesotrione is inspired by the natural substance leptospermone, which was first observed in 1977.
It inhibits the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), disrupting carotenoid biosynthesis.
This process leads to the destruction of chlorophyll, resulting in a bleaching effect in susceptible plants.

Analogs developed.
There were numerous changes in ownership of the teams formulating leptospermone inspired analogs.
USA and Europe
There are several patented ways to make the chemical sold as Mesotrione.
The vary in how repeatable the results are. The latest methods are less prone to necessitate discarding the batch.
According to the U.S. EPA, mesotrione is protected by U.S. Patent Nos. 5,006,158 and 5,698,493.
The compound patents expired in 2014, but Syngenta sold 88% of its mesotrione in mixtures still protected by patent.

Patent infringement case

Various Tank Mixes


Formulations include.
Version with Fertilizer

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Raspberry data submitted and not reviewed.



https://www.epa.gov/sites/default/files/2014-04/documents/mesotrione-response.pdf   

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Chemical